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Hua Medicine is an innovative drug development and commercialization company based in Shanghai, China. Hua Medicine focused on developing novel therapies for patients worldwide with unmet medical needs. Based on global resources, Hua Medicine teams up with global high-caliber people to develop breakthrough technologies and products, which contribute a global innovation in diabetes care.
Research Area
Science & Innovation
The Concept of Glucose Homeostasis
In Healthy Humans
Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.
In Patients with Type 2 Diabetes
Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.
Glucokinase Activator (GKA) Restores
A GKA can repair defective GK function and restore glucose homeostasis.
In Healthy Humans
Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.
In Patients with Type 2 Diabetes
Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.
Glucokinase Activator (GKA) Restores
A GKA can repair defective GK function and restore glucose homeostasis.
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